【讨论】猪流感疫苗：打还是不打？

[sage]

俺村的疫苗下周一开始。目前可以优先打的人有：

• 6个月－65岁有病史的
• 孕妇
• 健康的6个月－5岁儿童
• 医务工作者
• 护理6个月以下新生儿或者免疫系统有问题者

孕妇还可以选择不含辅助剂的猪流感疫苗，会在11月中旬出来。

[秋天的叶子]

我想打，我准备回国，国内这个流感也很厉害，不过不知道能不能约到

[redboy2000]

我自己没打过流感疫苗，也没给孩子打过。不是听说不少人打了之后反而有轻微的感染嘛，所以普通疫苗我肯定不打的，首先我都不相信那个可以预测得准每年流感的变异。但是诸流感我还在犹豫中，毕竟这个市有针对性的。

[xxn]

准备打，我家年年打，没觉得不好。

[sage]

加拿大今年的猪流感疫苗是加了辅助剂的，只用了普通不加辅助剂1／4的抗原。副作用就是在注射的地方容易发红，对人体倒是似乎并没有太大影响。

我们姑娘们的PD说会尽量推迟打这个针的时间，先观望一段。

[ForeverYoung]

我们家的好像每年都没打。这个新的应该也不会去打。

[redboy2000]

辅助即是什么？为什么加辅助记的反而抗原少很多？

[xxn]

作者: wiki

加拿大今年的猪流感疫苗是加了辅助剂的，只用了普通不加辅助剂1／4的抗原。副作用就是在注射的地方容易发红，对人体倒是似乎并没有太大影响。

我们姑娘们的PD说会尽量推迟打这个针的时间，先观望一段。

你家PD挺不错哦。我家的还没等我开口就堵上我的嘴了，不过我儿子去年一年就发烧了半天，我想大概是打预防针的好处吧，所以继续打。

[艾琳]

以下是公司发的邮件， 孕妇的那个问题是我问的。

A few of the questions I have been asked lately are:
I’m wondering if this vaccination uses a live or dead virus.
The H1N1 vaccination (inoculation) the we use in Canada does not contain live virus. Note: In some states in the USA they also use a nasal spray (FluMist) and that spray does contain live virus.
I’d like to have H1N1 flu shot, since I’m a commuter as well as pregnant. But I need to know this flu shot is safe to a pregnant woman or not?
The flu shot is safe for pregnant women, in fact they are on the priority list for those to be inoculated but if you have any concerns you can check with your doctor or call the health line and talk to a nurse. Health Link Alberta is a 24 hour a day, 7 day a week nurse telephone advice and health information service. You can call us from anywhere in the province by dialing: Calgary Health Region (403) 943-5465
(From the CDC) The seasonal flu shot has been given to millions of pregnant women over many years. Flu shots have not been shown to cause harm to pregnant women or their babies. The 2009 H1N1 flu shot is made in the same way and in the same places as the seasonal flu shot. It is very important for pregnant women to get both the seasonal flu shot and the 2009 H1N1 flu shot. Please see http://www.cdc.gov/h1n1flu/vaccination/ to learn more.

Do you have any information on the side-effects of the A/H1N1 influenza vaccination?
The side effects from 2009 H1N1 flu shots are expected to be like those from seasonal flu shots. The most common side effects after flu shots are mild, such as being sore and tender, red and swollen where the shot was given. Some people might have headache, muscle aches, fever, and nausea or feel tired. If these problems happen, they usually begin soon after the shot and may last as long as 1-2 days. Some people may faint after getting any shot. Sometimes, flu shots can cause serious problems like severe allergic reactions. But, life-threatening allergic reactions to vaccines are very rare. A person who has a severe (life-threatening) allergy to eggs or to anything else in the vaccine should not get the shot, even if she is pregnant.

[十之八九]

算了，不打，尽量少出门。

[花含烟]

我不太想给孩子打，因为每次打了疫苗都要高烧两天，跟真病了似的。

谁知这个疫苗有多大的效果？

先观望观望。

[sage]

作者: redboy2000

辅助即是什么？为什么加辅助记的反而抗原少很多？

辅助剂就是一种增强疫苗效果的东西，通常都在抗原缺少的情况下使用。
美国的猪流感疫苗没有加，但主要还是为的是加快疫苗批准速度。
今年加拿大的猪流感疫苗是添加了辅助剂的，而且是制药商(GlaxalSmithKline)自己的一种辅助剂，叫AS03。据说很安全，在欧洲已经使用了十几年了。不添加辅助剂的疫苗十一月中才会出来，是专门给孕妇使用的。

看看下面的文章：sample size太小了，而且还有很多未知数。我打算再等等。

September 14, 2009

Helen Branswell, Medical Reporter, THE CANADIAN PRESS

TORONTO - A shot of swine flu vaccine that is about a third of the size of a standard dose is protective when boosted with an additive called an adjuvant, Canada's pandemic vaccine manufacturer said Monday.

The ability to use one dose - and a small one at that - should both speed up the time it takes to fill an individual country's order and stretch limited global supplies of pandemic vaccine, experts have said.

Results of a clinical trial conducted in Europe by GlaxoSmithKline showed that 98 per cent of adults who received a single shot containing 5.25 micrograms of vaccine and the company's AS03 adjuvant had a spike in antibody levels thought to signal protection.

While a number of other companies have already shown that one shot of pandemic vaccine will likely protect most people, this is the smallest dose size that has been shown to be protective. Other companies have demonstrated that 15 micrograms of vaccine without adjuvant or 7.5 micrograms with adjuvant will probably protect against the new virus.

However, this trial does not answer the question of whether the dose GSK hopes to sell to Canada will work.

The company plans to sell a formulation containing 3.75 micrograms of antigen (vaccine) plus adjuvant. A statement from GSK said the formulation tested was "comparable to the expected final formulation of the adjuvanted vaccine."

An influenza expert said that may be true, but the company still needs to generate data showing that the smaller dose will work as well.

"The truth of the matter is if you have good immunogenicity with a 5.25 mcg dose, then, yeah, probably 3.75 mcg is going to be not bad. But it's clearly better to have data with the real dose," said Dr. Allison McGeer, an influenza expert at Toronto's Mount Sinai Hospital.

"The best data is obviously immunogenicity data that is as close as you can get to the actual vaccine that's being produced."

The Public Health Agency of Canada said these results and others released last week are promising but are not the final answer on dosing requirements.

"These preliminary results to date show that the vaccines help to protect people from the H1N1 strain. We will need additional data before making any final decisions about safety and effectiveness," Jirina Vlk, a spokeswoman for the agency, said in an email.

Though evidence is mounting that one shot of vaccine will protect adults against the novel H1N1 virus, Vlk said the public health agency is still hedging its bets. "Prudence dictates that we continue planning for a two-dose regime until we have more conclusive information on which to take a decision."

GSK did not explain in its release why it tested 5.25 mcg of vaccine with adjuvant and 21 mcg without. Neither dose size is among those routinely chosen for testing. Generally speaking clinical trials look at doses that are some fraction or multiple of 15 mcg, the amount of antigen per strain contained in a seasonal flu shot.

But the company said in an email that the clinical trial was started before standardized reagents - tests used to determine the concentration of vaccine - were available from the World Health Organization. Rather than wait for the standardized reagents, the company used alternative tests that appear to have led to higher-than-intended doses.

"Based on GSK's experience with its adjuvants systems, we do not anticipate that there will be any significant difference in the immune response elicited by the final formulation," GSK said in the email.

The GSK release also did not reveal whether there were any side-effects seen or how frequently they were reported. Studies done by other vaccine manufacturers have reported a side-effect profile for swine flu vaccine that is similar to what is seen with seasonal flu shots, mainly sore arms.

The release did say, though, that the findings have been shared with regulatory authorities and additional studies will be done in Europe, Canada and the United States.

"This trial provides encouraging data on the potential use of a single dose of our pandemic vaccine," said Jean Stephenne, president GlaxoSmithKline Biologicals.

"Our next step is to complete this trial, as well as 15 other studies in our clinical development programme for the vaccine."

The trial took place in Germany and involved 130 healthy volunteers 18 to 60 years old. GSK has two flu vaccine manufacturing facilities - one in Dresden, Germany and the other in St-Foy, Que. The latter will supply Canada's pandemic vaccine.

The company said 98 per cent of volunteers who got the small dose with adjuvant had antibody levels that exceeded what regulatory agencies consider is protective when tested three weeks after the shot was administered. Among those who got the larger dose of unadjuvanted vaccine, 95 per cent reached the same threshold.

Last week Novartis, Sanofi Pasteur and CSL Limited announced that their vaccines were protective with a single dose. And studies done by the U.S. National Institute of Allergy and Infectious Diseases showed that antibody levels reached the predicted protective threshold within eight to 10 days after one shot, which is very quick for vaccine.

Source: http://www.whistlerquestion.com/arti...template=cpArt

[toyo]

不打。

[美麗無罪]

我不会打，不知那反应如何！

[Cherryred]

不想打. 不过想知道这疫苗有效时间多长, 终生免疫还是要年年打?

[Sabrina08]

作者: wiki

俺村的疫苗下周一开始。目前可以优先打的人有：

• 6个月－65岁有病史的
• 孕妇
• 健康的6个月－5岁儿童
• 医务工作者
• 护理6个月以下新生儿或者免疫系统有问题者

孕妇还可以选择不含辅助剂的猪流感疫苗，会在11月中旬出来。

对疫苗有太多不好的经历了，小学时全校打麻疹疫苗，第二天我出了满头满脸的疹子，去医院看说是风疹还是荨麻疹来着，最主要是过了两三天是全校合唱比赛，我们班所有人跟我保持一尺以上的距离。

我女儿打完第三针乙肝疫苗出玫瑰疹。

[Cafe del Mar]

明年2月due，从来没打过疫苗，考虑再三还是不打了。

[悠然见南山]

唉，最近也在为这事闹心呢。儿子快11个月了，明年春天准备回国。我们从来没打过流感疫苗。年年单位打，我都不打，年年他们病，我都没病。真不想打。打吧，又怕他有什么反应，反倒闹出病。不打吧，又怕回国一折腾，染上病，再给隔离了。唉，大家多来讨论讨论吧。有了孩子人就是这么矛盾，不象没孩子那会，那叫一个潇洒呀，啥也不想。

[grace1123.]

作者: 悠然见南山

唉，最近也在为这事闹心呢。儿子快11个月了，明年春天准备回国。我们从来没打过流感疫苗。年年单位打，我都不打，年年他们病，我都没病。真不想打。打吧，又怕他有什么反应，反倒闹出病。不打吧，又怕回国一折腾，染上病，再给隔离了。唉，大家多来讨论讨论吧。有了孩子人就是这么矛盾，不象没孩子那会，那叫一个潇洒呀，...

same concern here.

[twinbabygirls]

送daycare的孩子，还是打吧。在家呆着的，父母又犹豫不定的，就算了，别折磨自己。